1. Round | 10/01/2021 | CF América | - | Atlético San Luis | 2:1 | ||||
2. Round | 16/01/2021 | Club Necaxa | - | Atlético San Luis | 1:0 | ||||
3. Round | 22/01/2021 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 | ||||
5. Round | 05/02/2021 | Atlético San Luis | - | Club Tijuana | 2:2 | ||||
6. Round | 13/02/2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
7. Round | 19/02/2021 | Atlético San Luis | - | Santos Laguna | 1:0 | ||||
14. Round | 10/04/2021 | FC Juárez | - | Atlético San Luis | 2:1 |