| 3. Round | 24/01/2021 | Gallos Blancos [U20] | - | Pumas UNAM [U20] | 1:3 |  |
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| 4. Round | 30/01/2021 | Pumas UNAM [U20] | - | Atlas Guadalajara [U20] | 0:2 | ||||
| 5. Round | 06/02/2021 | CF Monterrey [U20] | - | Pumas UNAM [U20] | 0:3 | ||||
| 6. Round | 14/02/2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 | ||||
| 7. Round | 21/02/2021 | Pumas UNAM [U20] | - | Club León [U20] | 1:4 | ||||
| 8. Round | 28/02/2021 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 1:2 | ||||
| 9. Round | 04/03/2021 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 10. Round | 07/03/2021 | Pumas UNAM [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 11. Round | 12/03/2021 | FC Juárez [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 13. Round | 04/04/2021 | Pumas UNAM [U20] | - | CF Pachuca [U20] | 4:4 | ||||
| 14. Round | 09/04/2021 | Club Necaxa [U20] | - | Pumas UNAM [U20] | 1:0 | ||||
| 15. Round | 18/04/2021 | Pumas UNAM [U20] | - | UANL Tigres [U20] | 2:4 | |
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| 16. Round | 23/04/2021 | Puebla FC [U20] | - | Pumas UNAM [U20] | 3:2 |
Mexico