| 1. Round | 15/08/2021 | Lommel SK | - | Waasland-Beveren | 2:3 | ||||
| 2. Round | 22/08/2021 | Waasland-Beveren | - | KMSK Deinze | 0:2 | ||||
| 3. Round | 29/08/2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 | ||||
| 4. Round | 12/09/2021 | Waasland-Beveren | - | KVC Westerlo | 0:2 |  |
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| 5. Round | 17/09/2021 | RWD Molenbeek | - | Waasland-Beveren | 1:3 | ||||
| 6. Round | 24/09/2021 | Lierse Kempenzonen | - | Waasland-Beveren | 2:1 |  |
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| 7. Round | 03/10/2021 | Waasland-Beveren | - | Excelsior Virton | 4:3 | ||||
| 8. Round | 15/10/2021 | KMSK Deinze | - | Waasland-Beveren | 0:0 | ||||
| 9. Round | 24/10/2021 | Waasland-Beveren | - | Lommel SK | 2:1 | ||||
| 10. Round | 30/10/2021 | Waasland-Beveren | - | Lierse Kempenzonen | 1:3 | ||||
| 11. Round | 07/11/2021 | KVC Westerlo | - | Waasland-Beveren | 1:1 | |
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| 12. Round | 19/11/2021 | Waasland-Beveren | - | Royal Excel Mouscron | 0:2 |
Faroe Islands