| 1. Round | 23/07/2021 | Club Necaxa [U20] | - | Santos Laguna [U20] | 3:0 |  |
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| 4. Round | 15/08/2021 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 5. Round | 18/08/2021 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 3:1 | ||||
| 10. Round | 26/09/2021 | Santos Laguna [U20] | - | CF Monterrey [U20] | 4:1 | ||||
| 16. Round | 30/10/2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 0:5 |
Mexico