| 1. Round | 03/07/2022 | CF América | - | Atlas Guadalajara | 0:0 | ||||
| 2. Round | 10/07/2022 | CF Monterrey | - | CF América | 3:2 | ||||
| 4. Round | 24/07/2022 | Club Tijuana | - | CF América | 2:0 | ||||
| 7. Round | 08/08/2022 | CF América | - | FC Juárez | 2:1 | ||||
| 8. Round | 14/08/2022 | Pumas UNAM | - | CF América | 0:3 | ||||
| 9. Round | 18/08/2022 | CF Pachuca | - | CF América | 0:3 | ||||
| 10. Round | 21/08/2022 | CF América | - | Cruz Azul | 7:0 |  |
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| 16. Round | 24/08/2022 | Gallos Blancos | - | CF América | 0:1 | |
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| 11. Round | 27/08/2022 | Mazatlán FC | - | CF América | 1:3 | ||||
| 13. Round | 07/09/2022 | CF América | - | Atlético San Luis | 3:0 | ||||
| 14. Round | 11/09/2022 | Club Necaxa | - | CF América | 1:2 |  |
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| 15. Round | 18/09/2022 | CF América | - | Deportivo Guadalajara | 2:1 | ||||
| 17. Round | 01/10/2022 | Puebla FC | - | CF América | 1:2 |
Mexico
Spain