| 1. Round | 14/08/2021 | Arminia Bielefeld | - | SC Freiburg | 0:0 | ||||
| 2. Round | 21/08/2021 | SC Freiburg | - | Borussia Dortmund | 2:1 | ||||
| 21. Round | 05/02/2022 | 1. FC Köln | - | SC Freiburg | 1:0 | ||||
| 23. Round | 19/02/2022 | FC Augsburg | - | SC Freiburg | 1:2 | ||||
| 26. Round | 12/03/2022 | SC Freiburg | - | VfL Wolfsburg | 3:2 | ||||
| 27. Round | 19/03/2022 | SpVgg Greuther Fürth | - | SC Freiburg | 0:0 | ||||
| 28. Round | 02/04/2022 | SC Freiburg | - | Bayern München | 1:4 | ||||
| 29. Round | 10/04/2022 | Eintracht Frankfurt | - | SC Freiburg | 1:2 | ||||
| 30. Round | 16/04/2022 | SC Freiburg | - | VfL Bochum | 3:0 | ||||
| 31. Round | 23/04/2022 | SC Freiburg | - | Bor. Mönchengladbach | 3:3 | ||||
| 32. Round | 30/04/2022 | 1899 Hoffenheim | - | SC Freiburg | 3:4 | ||||
| 33. Round | 07/05/2022 | SC Freiburg | - | 1. FC Union Berlin | 1:4 | ||||
| 34. Round | 14/05/2022 | Bayer Leverkusen | - | SC Freiburg | 2:1 |
France