| 12. Round | 31/01/2021 | UCAM Murcia CF | - | Córdoba CF | 1:1 | ||||
| 13. Round | 07/02/2021 | CD El Ejido 2012 | - | UCAM Murcia CF | 1:1 |  |
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| 14. Round | 14/02/2021 | UCAM Murcia CF | - | Real Betis B | 1:1 |  |
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| 15. Round | 20/02/2021 | Lorca Deportiva | - | UCAM Murcia CF | 1:2 | |
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| 16. Round | 06/03/2021 | UCAM Murcia CF | - | Yeclano Deportivo | 1:0 | |
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| 17. Round | 14/03/2021 | UCAM Murcia CF | - | Real Murcia | 1:1 | |
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| 18. Round | 21/03/2021 | Recreativo Granada | - | UCAM Murcia CF | 1:2 |
Spain