| 7. Round | 20/08/2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 8. Round | 27/08/2022 | General Caballero DJLM | - | Cerro Porteño | 1:1 |  |
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| 9. Round | 03/09/2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | ||||
| 10. Round | 13/09/2022 | General Caballero DJLM | - | 12 de Octubre de Itauguá | 2:1 | ||||
| 11. Round | 17/09/2022 | Sol de América | - | General Caballero DJLM | 3:2 | ||||
| 12. Round | 19/09/2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
| 13. Round | 24/09/2022 | General Caballero DJLM | - | Guaraní | 3:0 | ||||
| 14. Round | 02/10/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 15. Round | 05/10/2022 | General Caballero DJLM | - | Guaireña FC | 0:0 | |
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| 16. Round | 12/10/2022 | Tacuary | - | General Caballero DJLM | 0:3 | ||||
| 17. Round | 15/10/2022 | General Caballero DJLM | - | Sportivo Ameliano | 2:0 | ||||
| 18. Round | 22/10/2022 | Club Olimpia | - | General Caballero DJLM | 2:1 | ||||
| 19. Round | 28/10/2022 | Cerro Porteño | - | General Caballero DJLM | 2:1 | ||||
| 21. Round | 08/11/2022 | 12 de Octubre de Itauguá | - | General Caballero DJLM | 0:3 |  |
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Paraguay