3. Round | 19/02/2022 | River Plate | - | Boston River | 1:2 | ||||
4. Round | 25/02/2022 | Boston River | - | Cerro Largo | 3:0 | ||||
5. Round | 12/03/2022 | Fénix | - | Boston River | 0:2 | ||||
6. Round | 21/03/2022 | Boston River | - | Defensor Sporting | 1:1 | ||||
7. Round | 02/04/2022 | Albion | - | Boston River | 1:2 | ||||
13. Round | 21/05/2022 | Peñarol | - | Boston River | 1:0 |