| 2. Round | 30/01/2016 | Club Olimpia | - | Libertad | 1:0 | ||||
| 3. Round | 04/02/2016 | Libertad | - | Sol de América | 1:2 | ||||
| 4. Round | 08/02/2016 | Libertad | - | River Plate | 3:1 | ||||
| 5. Round | 14/02/2016 | Club Nacional | - | Libertad | 1:3 | ||||
| 6. Round | 20/02/2016 | Libertad | - | Deportivo Capiatá | 4:2 | ||||
| 7. Round | 26/02/2016 | General Díaz | - | Libertad | 1:0 | ||||
| 8. Round | 02/03/2016 | Libertad | - | Cerro Porteño | 2:1 | ||||
| 9. Round | 06/03/2016 | Sportivo Luqueño | - | Libertad | 0:1 |  |
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| 10. Round | 11/03/2016 | Libertad | - | General Caballero ZC | 2:2 | |
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| 11. Round | 20/03/2016 | Guaraní | - | Libertad | 1:3 | |
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| 1. Round | 26/03/2016 | Libertad | - | Club Rubio Ñu | 0:1 | ||||
| 12. Round | 03/04/2016 | Club Rubio Ñu | - | Libertad | 2:0 |
Paraguay