| 1. Round | 03/07/2022 | Pumas UNAM | - | Club Tijuana | 1:1 | ||||
| 2. Round | 10/07/2022 | Club León | - | Pumas UNAM | 3:3 |  |
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| 3. Round | 17/07/2022 | Pumas UNAM | - | Club Necaxa | 1:0 | ||||
| 4. Round | 25/07/2022 | CF Pachuca | - | Pumas UNAM | 0:0 | ||||
| 9. Round | 19/08/2022 | Atlético San Luis | - | Pumas UNAM | 3:2 | |
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| 10. Round | 21/08/2022 | Pumas UNAM | - | Santos Laguna | 1:5 | ||||
| 11. Round | 28/08/2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
| 12. Round | 04/09/2022 | Atlas Guadalajara | - | Pumas UNAM | 0:0 | ||||
| 13. Round | 08/09/2022 | Pumas UNAM | - | Gallos Blancos | 4:1 |  |
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| 14. Round | 11/09/2022 | Deportivo Toluca | - | Pumas UNAM | 2:2 | ||||
| 15. Round | 18/09/2022 | Pumas UNAM | - | Cruz Azul | 1:2 | |
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| 7. Round | 24/09/2022 | Puebla FC | - | Pumas UNAM | 2:1 | ||||
| 17. Round | 01/10/2022 | FC Juárez | - | Pumas UNAM | 3:1 |
USA
Mexico