2. Round | 25/07/2021 | Guaireña FC | - | River Plate | 1:2 | ||||
10. Round | 27/09/2021 | Guaireña FC | - | Libertad | 2:1 | ||||
11. Round | 03/10/2021 | River Plate | - | Guaireña FC | 1:1 | ||||
12. Round | 18/10/2021 | Guaireña FC | - | Club Olimpia | 0:2 | ||||
13. Round | 25/10/2021 | Guaireña FC | - | Cerro Porteño | 0:2 | ||||
14. Round | 31/10/2021 | Sol de América | - | Guaireña FC | 3:0 | ||||
15. Round | 08/11/2021 | Guaireña FC | - | Club Nacional | 0:0 | ||||
16. Round | 19/11/2021 | 12 de Octubre de Itauguá | - | Guaireña FC | 0:0 | ||||
17. Round | 28/11/2021 | Guaireña FC | - | Guaraní | 1:1 |