| 1. Round | 16/07/2021 | Unión de Santa Fe | - | Boca Juniors | 1:1 |  |
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| 5. Round | 08/08/2021 | Boca Juniors | - | Argentinos Juniors | 1:1 | |
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| 8. Round | 26/08/2021 | Platense | - | Boca Juniors | 1:3 | ||||
| 10. Round | 05/09/2021 | Rosario Central | - | Boca Juniors | 1:2 | |
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| 11. Round | 15/09/2021 | Boca Juniors | - | Defensa y Justicia | 0:0 | ||||
| 12. Round | 19/09/2021 | Atlético Tucumán | - | Boca Juniors | 1:2 | |
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| 14. Round | 03/10/2021 | River Plate | - | Boca Juniors | 2:1 | ||||
| 15. Round | 10/10/2021 | Boca Juniors | - | Lanús | 4:2 | |
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| 17. Round | 21/10/2021 | Boca Juniors | - | Godoy Cruz | 2:1 | ||||
| 18. Round | 25/10/2021 | Vélez Sarsfield | - | Boca Juniors | 2:0 | ||||
| 20. Round | 09/11/2021 | Aldosivi | - | Boca Juniors | 0:3 | ||||
| 21. Round | 20/11/2021 | Boca Juniors | - | Sarmiento de Junín | 2:0 | ||||
| 23. Round | 30/11/2021 | Boca Juniors | - | Newell's Old Boys | 0:0 | ||||
| 24. Round | 04/12/2021 | Arsenal de Sarandí | - | Boca Juniors | 1:1 |
Colombia
Argentina