| 7. Round | 26/02/2022 | CF Monterrey | - | Atlético San Luis | 0:2 | ||||
| 8. Round | 02/03/2022 | Club León | - | CF Monterrey | 0:0 | ||||
| 9. Round | 06/03/2022 | CF Monterrey | - | CF América | 2:1 | ||||
| 10. Round | 12/03/2022 | CF Monterrey | - | Mazatlán FC | 2:1 | ||||
| 5. Round | 16/03/2022 | CF Monterrey | - | FC Juárez | 3:0 |  |
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| 11. Round | 20/03/2022 | UANL Tigres | - | CF Monterrey | 2:0 | ||||
| 4. Round | 07/04/2022 | Deportivo Toluca | - | CF Monterrey | 2:2 | ||||
| 13. Round | 10/04/2022 | CF Monterrey | - | Santos Laguna | 1:0 | ||||
| 12. Round | 14/04/2022 | Deportivo Guadalajara | - | CF Monterrey | 1:3 | ||||
| 14. Round | 17/04/2022 | Pumas UNAM | - | CF Monterrey | 2:0 | ||||
| 16. Round | 23/04/2022 | CF Pachuca | - | CF Monterrey | 3:0 | ||||
| 17. Round | 01/05/2022 | CF Monterrey | - | Club Tijuana | 2:0 |
Mexico