| 1. Round | 06/01/2022 | Atlético San Luis [U20] | - | CF Pachuca [U20] | 0:2 | ||||
| 4. Round | 05/02/2022 | CF América [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 7. Round | 26/02/2022 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 11. Round | 17/03/2022 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 3:0 | ||||
| 12. Round | 01/04/2022 | Atlético San Luis [U20] | - | Mazatlán FC [U20] | 1:2 | ||||
| 9. Round | 06/04/2022 | Club Tijuana [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 14. Round | 15/04/2022 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 3:0 |
Mexico