| 16. Round | 25/08/2022 | Pumas UNAM | - | UANL Tigres | 1:1 | ||||
| 11. Round | 28/08/2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
| 12. Round | 04/09/2022 | Atlas Guadalajara | - | Pumas UNAM | 0:0 | ||||
| 13. Round | 08/09/2022 | Pumas UNAM | - | Gallos Blancos | 4:1 | ||||
| 14. Round | 11/09/2022 | Deportivo Toluca | - | Pumas UNAM | 2:2 |  |
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| 15. Round | 18/09/2022 | Pumas UNAM | - | Cruz Azul | 1:2 | ||||
| 7. Round | 24/09/2022 | Puebla FC | - | Pumas UNAM | 2:1 | ||||
| 17. Round | 01/10/2022 | FC Juárez | - | Pumas UNAM | 3:1 |
Colombia