| 3. Round | 09/08/2021 | CF Pachuca [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 4. Round | 14/08/2021 | CF Monterrey [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 6. Round | 22/08/2021 | Gallos Blancos [U20] | - | CF Pachuca [U20] | 1:2 |  |
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| 7. Round | 29/08/2021 | Cruz Azul [U20] | - | CF Pachuca [U20] | 0:0 | ||||
| 8. Round | 13/09/2021 | CF Pachuca [U20] | - | Deportivo Toluca [U20] | 2:0 | ||||
| 9. Round | 18/09/2021 | Deportivo Guadalajara [U20] | - | CF Pachuca [U20] | 1:2 |  |
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| 10. Round | 23/09/2021 | CF Pachuca [U20] | - | Club Necaxa [U20] | 1:1 | ||||
| 11. Round | 28/09/2021 | CF Pachuca [U20] | - | CF América [U20] | 1:2 | ||||
| 12. Round | 01/10/2021 | Puebla FC [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 16. Round | 30/10/2021 | CF Pachuca [U20] | - | Pumas UNAM [U20] | 1:0 | |
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| 5. Round | 03/11/2021 | CF Pachuca [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 17. Round | 10/11/2021 | Club Tijuana [U20] | - | CF Pachuca [U20] | 2:1 |
Mexico