| 1. Round | 25/07/2021 | Club Tijuana [U18] | - | UANL Tigres [U18] | 1:0 | ||||
| 2. Round | 31/07/2021 | Club León [U18] | - | Club Tijuana [U18] | 2:1 | ||||
| 7. Round | 27/08/2021 | Club Tijuana [U18] | - | CF Monterrey [U18] | 0:0 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 13. Round | 14/10/2021 | Gallos Blancos [U18] | - | Club Tijuana [U18] | 2:0 |
Mexico