| 6. Round | 02/09/2021 | Club Celaya | - | Pumas Tabasco | 1:2 | ||||
| 7. Round | 09/09/2021 | Pumas Tabasco | - | Atlante | 0:2 | ||||
| 8. Round | 15/09/2021 | Correcaminos UAT | - | Pumas Tabasco | 0:2 | ||||
| 9. Round | 23/09/2021 | Pumas Tabasco | - | Venados FC | 1:1 | ||||
| 10. Round | 01/10/2021 | Cimarrones de Sonora | - | Pumas Tabasco | 2:1 | ||||
| 13. Round | 20/10/2021 | Pumas Tabasco | - | Cancún FC | 0:0 | ||||
| 14. Round | 29/10/2021 | Atlético Morelia | - | Pumas Tabasco | 0:1 | ||||
| 17. Round | 17/11/2021 | TM Fútbol Club | - | Pumas Tabasco | 1:1 |
Mexico