| 11. Round | 27/08/2022 | Cruz Azul | - | Gallos Blancos | 2:1 |  |
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| 12. Round | 03/09/2022 | FC Juárez | - | Cruz Azul | 2:2 | ||||
| 13. Round | 07/09/2022 | CF Monterrey | - | Cruz Azul | 3:2 | ||||
| 14. Round | 11/09/2022 | Cruz Azul | - | Mazatlán FC | 2:0 | ||||
| 16. Round | 16/09/2022 | Cruz Azul | - | Club León | 2:1 | ||||
| 15. Round | 18/09/2022 | Pumas UNAM | - | Cruz Azul | 1:2 | ||||
| 17. Round | 02/10/2022 | Cruz Azul | - | Deportivo Guadalajara | 2:1 |
Mexico