| 4. Round | 06/02/2022 | CF América | - | Atlético San Luis | 2:3 | ||||
| 6. Round | 20/02/2022 | UANL Tigres | - | Atlético San Luis | 2:1 | ||||
| 11. Round | 18/03/2022 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 12. Round | 02/04/2022 | Atlético San Luis | - | Mazatlán FC | 1:0 | ||||
| 9. Round | 07/04/2022 | Club Tijuana | - | Atlético San Luis | 1:1 | ||||
| 17. Round | 01/05/2022 | Atlético San Luis | - | Santos Laguna | 1:3 |
Mexico