| 2. Round | 25/09/2021 | Catedráticos Elite | - | Mineros de Fresnillo FC | 3:1 | ||||
| 5. Round | 13/10/2021 | Mineros de Fresnillo FC | - | Tecos Fútbol Club | 1:1 | ||||
| 6. Round | 17/10/2021 | Colima FC | - | Mineros de Fresnillo FC | 5:0 | ||||
| 8. Round | 30/10/2021 | Coras de Nayarit | - | Mineros de Fresnillo FC | 4:0 | ||||
| 9. Round | 06/11/2021 | Correcaminos UAT II | - | Mineros de Fresnillo FC | 3:0 |
Mexico