| 1. Round | 25/07/2021 | Club Tijuana [U18] | - | UANL Tigres [U18] | 1:0 |  |
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| 2. Round | 31/07/2021 | Club León [U18] | - | Club Tijuana [U18] | 2:1 | ||||
| 3. Round | 06/08/2021 | Club Tijuana [U18] | - | Deportivo Toluca [U18] | 3:0 | ||||
| 4. Round | 13/08/2021 | FC Juárez [U18] | - | Club Tijuana [U18] | 3:2 | |
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| 5. Round | 17/08/2021 | Club Tijuana [U18] | - | Puebla FC [U18] | 5:2 | ||||
| 6. Round | 22/08/2021 | CF América [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 7. Round | 27/08/2021 | Club Tijuana [U18] | - | CF Monterrey [U18] | 0:0 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 9. Round | 16/09/2021 | Atlético San Luis [U18] | - | Club Tijuana [U18] | 1:0 | ||||
| 10. Round | 24/09/2021 | Club Tijuana [U18] | - | Mazatlán FC [U18] | 1:2 | ||||
| 11. Round | 28/09/2021 | Club Necaxa [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 14. Round | 20/10/2021 | Club Tijuana [U18] | - | Deportivo Guadalajara [U18] | 1:3 |
Mexico