| 1. Round | 08/01/2022 | Cruz Azul [U18] | - | Club Tijuana [U18] | 3:2 |  |
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| 2. Round | 15/01/2022 | Club Tijuana [U18] | - | Club León [U18] | 1:2 | ||||
| 4. Round | 05/02/2022 | Club Tijuana [U18] | - | Pumas UNAM [U18] | 2:0 |  |
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| 5. Round | 11/02/2022 | Mazatlán FC [U18] | - | Club Tijuana [U18] | 0:2 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U18] | - | Club Necaxa [U18] | 3:2 | |
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| 7. Round | 25/02/2022 | Club Tijuana [U18] | - | Atlas Guadalajara [U18] | 3:3 | ||||
| 8. Round | 01/03/2022 | Deportivo Toluca [U18] | - | Club Tijuana [U18] | 1:1 | |
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| 10. Round | 12/03/2022 | Santos Laguna [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 11. Round | 18/03/2022 | Club Tijuana [U18] | - | FC Juárez [U18] | 3:2 | ||||
| 12. Round | 03/04/2022 | UANL Tigres [U18] | - | Club Tijuana [U18] | 2:0 | ||||
| 9. Round | 06/04/2022 | Club Tijuana [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 13. Round | 11/04/2022 | CF Pachuca [U18] | - | Club Tijuana [U18] | 1:2 | ||||
| 14. Round | 15/04/2022 | Club Tijuana [U18] | - | CF América [U18] | 2:0 |
Mexico