| 6. Round | 20/02/2022 | Club León | - | Deportivo Guadalajara | 2:1 | ||||
| 7. Round | 27/02/2022 | Deportivo Guadalajara | - | Puebla FC | 2:3 | ||||
| 8. Round | 03/03/2022 | Atlético San Luis | - | Deportivo Guadalajara | 2:2 | ||||
| 9. Round | 06/03/2022 | Deportivo Guadalajara | - | Santos Laguna | 1:0 |  |
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| 10. Round | 13/03/2022 | Deportivo Guadalajara | - | CF América | 0:0 | ||||
| 11. Round | 21/03/2022 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 | ||||
| 13. Round | 10/04/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 1:1 | |
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| 12. Round | 14/04/2022 | Deportivo Guadalajara | - | CF Monterrey | 1:3 |
Mexico