| 1. Round | 06/06/2022 | Defensa y Justicia | - | River Plate | 0:0 | ||||
| 2. Round | 12/06/2022 | River Plate | - | Atlético Tucumán | 0:0 | ||||
| 3. Round | 15/06/2022 | Colón de Santa Fe | - | River Plate | 1:0 | ||||
| 4. Round | 19/06/2022 | Unión de Santa Fe | - | River Plate | 1:5 | ||||
| 5. Round | 26/06/2022 | River Plate | - | Lanús | 2:1 |  |
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| 6. Round | 04/07/2022 | Huracán | - | River Plate | 3:2 | ||||
| 7. Round | 11/07/2022 | River Plate | - | Godoy Cruz | 0:2 | ||||
| 8. Round | 18/07/2022 | Vélez Sarsfield | - | River Plate | 2:2 | ||||
| 11. Round | 01/08/2022 | River Plate | - | Sarmiento de Junín | 1:2 | ||||
| 14. Round | 17/08/2022 | Arsenal de Sarandí | - | River Plate | 0:0 | ||||
| 21. Round | 24/09/2022 | River Plate | - | Talleres de Córdoba | 0:1 | ||||
| 23. Round | 06/10/2022 | River Plate | - | Estudiantes | 5:0 | ||||
| 24. Round | 10/10/2022 | Patronato de Paraná | - | River Plate | 0:1 |  |
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| 26. Round | 17/10/2022 | River Plate | - | Rosario Central | 1:2 | ||||
| 27. Round | 23/10/2022 | Racing Club | - | River Plate | 1:2 |
Argentina