| 1. Round | 10/01/2021 | UANL Tigres | - | Club León | 2:0 | ||||
| 2. Round | 19/01/2021 | Club León | - | CF Pachuca | 0:0 | ||||
| 4. Round | 02/02/2021 | Club León | - | Atlético San Luis | 3:1 | ||||
| 5. Round | 09/02/2021 | Club León | - | Deportivo Guadalajara | 1:3 | ||||
| 6. Round | 13/02/2021 | Club Tijuana | - | Club León | 2:0 | ||||
| 7. Round | 21/02/2021 | Pumas UNAM | - | Club León | 0:1 | ||||
| 8. Round | 28/02/2021 | Club León | - | Cruz Azul | 0:1 | ||||
| 9. Round | 03/03/2021 | Club León | - | Puebla FC | 1:2 | ||||
| 10. Round | 07/03/2021 | CF América | - | Club León | 2:1 | ||||
| 3. Round | 11/03/2021 | CF Monterrey | - | Club León | 1:1 | ||||
| 11. Round | 16/03/2021 | Club León | - | Club Necaxa | 3:1 | ||||
| 12. Round | 22/03/2021 | Santos Laguna | - | Club León | 1:2 | ||||
| 13. Round | 05/04/2021 | Club León | - | Deportivo Toluca | 2:1 |  |
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| 14. Round | 10/04/2021 | Atlas Guadalajara | - | Club León | 1:3 | ||||
| 15. Round | 20/04/2021 | Club León | - | FC Juárez | 2:0 | ||||
| 16. Round | 24/04/2021 | Mazatlán FC | - | Club León | 4:3 | ||||
| 17. Round | 01/05/2021 | Club León | - | Gallos Blancos | 2:1 |
Mexico