| 1. Round | 10/01/2021 | UANL Tigres | - | Club León | 2:0 | ||||
| 2. Round | 19/01/2021 | Club León | - | CF Pachuca | 0:0 |  |
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| 4. Round | 02/02/2021 | Club León | - | Atlético San Luis | 3:1 | ||||
| 5. Round | 09/02/2021 | Club León | - | Deportivo Guadalajara | 1:3 | ||||
| 6. Round | 13/02/2021 | Club Tijuana | - | Club León | 2:0 | ||||
| 7. Round | 21/02/2021 | Pumas UNAM | - | Club León | 0:1 | ||||
| 3. Round | 11/03/2021 | CF Monterrey | - | Club León | 1:1 |
Mexico