1. Round | 18/09/2021 | FC Juárez [] | - | Puebla FC [] | 1:0 | ||||
2. Round | 25/09/2021 | Puebla FC [] | - | Deportivo Toluca [] | 2:1 | ||||
3. Round | 02/10/2021 | CF Pachuca [] | - | Puebla FC [] | 4:0 | ||||
9. Round | 13/11/2021 | CF América [] | - | Puebla FC [] | 6:1 | ||||
10. Round | 20/11/2021 | Puebla FC [] | - | Pumas UNAM [] | 2:4 |