| 1. Round | 24/07/2021 | CF Pachuca [U20] | - | Club León [U20] | 0:1 | ||||
| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 16. Round | 31/10/2021 | Deportivo Toluca [U20] | - | Club León [U20] | 1:0 | ||||
| 11. Round | 03/11/2021 | Cruz Azul [U20] | - | Club León [U20] | 2:0 | ||||
| 17. Round | 06/11/2021 | Club León [U20] | - | Club Necaxa [U20] | 3:1 |  |
Mexico