| 1. Round | 03/07/2022 | Pumas UNAM | - | Club Tijuana | 1:1 | ||||
| 2. Round | 09/07/2022 | Club Tijuana | - | FC Juárez | 0:2 | ||||
| 3. Round | 18/07/2022 | UANL Tigres | - | Club Tijuana | 1:0 | ||||
| 4. Round | 24/07/2022 | Club Tijuana | - | CF América | 2:0 | ||||
| 5. Round | 27/07/2022 | Atlas Guadalajara | - | Club Tijuana | 1:2 |  |
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| 6. Round | 31/07/2022 | Club Tijuana | - | Mazatlán FC | 2:0 | ||||
| 7. Round | 07/08/2022 | Deportivo Toluca | - | Club Tijuana | 3:1 | ||||
| 8. Round | 13/08/2022 | Club Tijuana | - | Puebla FC | 3:3 | ||||
| 9. Round | 18/08/2022 | Cruz Azul | - | Club Tijuana | 1:2 | ||||
| 10. Round | 20/08/2022 | Gallos Blancos | - | Club Tijuana | 2:0 | |
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| 16. Round | 26/08/2022 | Club Tijuana | - | Santos Laguna | 0:2 | ||||
| 11. Round | 29/08/2022 | Club Tijuana | - | CF Monterrey | 0:3 | ||||
| 12. Round | 02/09/2022 | Atlético San Luis | - | Club Tijuana | 0:0 | ||||
| 13. Round | 08/09/2022 | Club Tijuana | - | Deportivo Guadalajara | 1:2 | ||||
| 14. Round | 12/09/2022 | CF Pachuca | - | Club Tijuana | 6:1 | ||||
| 15. Round | 19/09/2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 17. Round | 03/10/2022 | Club León | - | Club Tijuana | 2:2 | |
Mexico