| 1. Round | 23/08/1980 | CS Chênois | - | FC Chiasso | 1:1 | ||||
| 2. Round | 30/08/1980 | FC Chiasso | - | FC Zürich | 0:1 | ||||
| 3. Round | 06/09/1980 | FC St. Gallen | - | FC Chiasso | 1:1 | ||||
| 4. Round | 13/09/1980 | Grasshopper Club Zürich | - | FC Chiasso | 2:1 | ||||
| 5. Round | 20/09/1980 | FC Chiasso | - | FC Basel 1893 | 3:0 | ||||
| 6. Round | 04/10/1980 | FC Sion | - | FC Chiasso | 5:0 |  |
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| 7. Round | 08/10/1980 | FC Chiasso | - | BSC Young Boys | 1:1 | ||||
| 8. Round | 11/10/1980 | FC Chiasso | - | Neuchâtel Xamax FC | 1:1 | |
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| 10. Round | 25/10/1980 | FC Chiasso | - | FC Luzern | 1:1 | ||||
| 11. Round | 15/11/1980 | AC Bellinzona | - | FC Chiasso | 2:0 | ||||
| 12. Round | 23/11/1980 | FC Chiasso | - | FC Nordstern Basel | 4:3 |  |
Croatia