| 1. Round | 25/07/2021 | Lokomotiv Plovdiv | - | PFC Ludogorets Razgrad | 1:3 | ||||
| 2. Round | 31/07/2021 | PFC Ludogorets Razgrad | - | CSKA 1948 Sofia | 3:0 | ||||
| 5. Round | 21/08/2021 | PFC Ludogorets Razgrad | - | Lokomotiv Sofia | 5:0 |  |
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| 6. Round | 29/08/2021 | Pirin Blagoevgrad | - | PFC Ludogorets Razgrad | 1:3 | |
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| 7. Round | 11/09/2021 | PFC Ludogorets Razgrad | - | Cherno More Varna | 2:0 | ||||
| 8. Round | 19/09/2021 | Slavia Sofia | - | PFC Ludogorets Razgrad | 1:0 | ||||
| 9. Round | 26/09/2021 | PFC Ludogorets Razgrad | - | Botev Vratsa | 3:1 | ||||
| 11. Round | 16/10/2021 | PFC Ludogorets Razgrad | - | Tsarsko Selo Sofia | 4:0 | |
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| 12. Round | 25/10/2021 | Botev Plovdiv | - | PFC Ludogorets Razgrad | 1:3 | ||||
| 13. Round | 31/10/2021 | PFC Ludogorets Razgrad | - | PFC Beroe | 2:0 |
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