| 1. Round | 25/06/2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 1:0 | ||||
| 2. Round | 03/07/2022 | Deportivo Guadalajara [U16] | - | Atlas Guadalajara [U16] | 2:1 | ||||
| 3. Round | 09/07/2022 | UANL Tigres [U16] | - | Deportivo Guadalajara [U16] | 1:3 | ||||
| 7. Round | 06/08/2022 | Deportivo Guadalajara [U16] | - | CF Monterrey [U16] | 3:2 | ||||
| 8. Round | 13/08/2022 | Atlético San Luis [U16] | - | Deportivo Guadalajara [U16] | 0:0 | ||||
| 9. Round | 20/08/2022 | Deportivo Guadalajara [U16] | - | Mazatlán FC [U16] | 3:1 | ||||
| 10. Round | 27/08/2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 1:0 |  |
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| 11. Round | 03/09/2022 | Mazatlán FC [U16] | - | Deportivo Guadalajara [U16] | 1:2 | ||||
| 13. Round | 17/09/2022 | CF Monterrey [U16] | - | Deportivo Guadalajara [U16] | 1:1 | |
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| 14. Round | 25/09/2022 | Deportivo Guadalajara [U16] | - | Club Tijuana [U16] | 4:1 | |
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| 17. Round | 15/10/2022 | Deportivo Guadalajara [U16] | - | UANL Tigres [U16] | 3:1 | ||||
| 18. Round | 22/10/2022 | Atlas Guadalajara [U16] | - | Deportivo Guadalajara [U16] | 1:2 | |
Mexico