| 1. Round | 04/06/2022 | San Lorenzo | - | Independiente | 1:1 | ||||
| 2. Round | 11/06/2022 | Independiente | - | Talleres de Córdoba | 1:0 | ||||
| 3. Round | 16/06/2022 | Argentinos Juniors | - | Independiente | 2:1 | ||||
| 4. Round | 21/06/2022 | Independiente | - | Estudiantes | 2:1 | ||||
| 5. Round | 27/06/2022 | Patronato de Paraná | - | Independiente | 3:1 | ||||
| 6. Round | 05/07/2022 | Independiente | - | Platense | 1:3 | ||||
| 7. Round | 10/07/2022 | Racing Club | - | Independiente | 1:0 | ||||
| 9. Round | 20/07/2022 | Defensa y Justicia | - | Independiente | 2:1 | ||||
| 10. Round | 24/07/2022 | Independiente | - | Atlético Tucumán | 0:1 | ||||
| 12. Round | 07/08/2022 | Independiente | - | River Plate | 0:1 |  |
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| 17. Round | 04/09/2022 | Gimnasia de La Plata | - | Independiente | 3:1 | ||||
| 24. Round | 09/10/2022 | Tigre | - | Independiente | 2:1 | ||||
| 25. Round | 12/10/2022 | Independiente | - | Barracas Central | 2:2 |  |
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| 26. Round | 16/10/2022 | Independiente | - | Banfield | 1:0 | ||||
| 27. Round | 23/10/2022 | Boca Juniors | - | Independiente | 2:2 |
Ecuador