| 1. Round | 25/07/2021 | Club Tijuana [U18] | - | UANL Tigres [U18] | 1:0 | ||||
| 2. Round | 31/07/2021 | Club León [U18] | - | Club Tijuana [U18] | 2:1 | ||||
| 3. Round | 06/08/2021 | Club Tijuana [U18] | - | Deportivo Toluca [U18] | 3:0 | ||||
| 6. Round | 22/08/2021 | CF América [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 7. Round | 27/08/2021 | Club Tijuana [U18] | - | CF Monterrey [U18] | 0:0 | ||||
| 10. Round | 24/09/2021 | Club Tijuana [U18] | - | Mazatlán FC [U18] | 1:2 | ||||
| 11. Round | 28/09/2021 | Club Necaxa [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U18] | - | Cruz Azul [U18] | 3:2 |
Mexico