| 3. Round | 07/08/2021 | Deportivo Guadalajara [U18] | - | FC Juárez [U18] | 1:2 | ||||
| 4. Round | 15/08/2021 | Santos Laguna [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U18] | - | Club León [U18] | 1:1 | ||||
| 6. Round | 21/08/2021 | CF Monterrey [U18] | - | Deportivo Guadalajara [U18] | 2:2 | ||||
| 9. Round | 18/09/2021 | Deportivo Guadalajara [U18] | - | CF Pachuca [U18] | 0:4 | ||||
| 10. Round | 25/09/2021 | CF América [U18] | - | Deportivo Guadalajara [U18] | 5:1 | ||||
| 11. Round | 29/09/2021 | Gallos Blancos [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 12. Round | 02/10/2021 | Deportivo Guadalajara [U18] | - | Atlas Guadalajara [U18] | 3:0 | ||||
| 13. Round | 17/10/2021 | Deportivo Guadalajara [U18] | - | Deportivo Toluca [U18] | 2:2 |  |
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| 14. Round | 20/10/2021 | Club Tijuana [U18] | - | Deportivo Guadalajara [U18] | 1:3 | ||||
| 15. Round | 23/10/2021 | Deportivo Guadalajara [U18] | - | Cruz Azul [U18] | 2:1 |
Mexico