| 3. Round | 08/08/2021 | Pumas UNAM [U20] | - | Atlético San Luis [U20] | 5:3 |  |
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| 4. Round | 14/08/2021 | Pumas UNAM [U20] | - | Gallos Blancos [U20] | 1:4 | ||||
| 5. Round | 17/08/2021 | Club Necaxa [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 6. Round | 22/08/2021 | Pumas UNAM [U20] | - | Puebla FC [U20] | 1:3 | ||||
| 7. Round | 29/08/2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 | ||||
| 8. Round | 12/09/2021 | Pumas UNAM [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 10. Round | 25/09/2021 | UANL Tigres [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 15. Round | 24/10/2021 | Pumas UNAM [U20] | - | Club Tijuana [U20] | 4:0 |
Paraguay