| 1. Round | 14/10/2020 | Mushuc Runa | - | Independiente del Valle | 3:2 |  |
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| 2. Round | 18/10/2020 | El Nacional | - | Mushuc Runa | 2:1 | ||||
| 3. Round | 23/10/2020 | Mushuc Runa | - | Aucas | 1:4 |  |
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| 5. Round | 05/11/2020 | Macará | - | Mushuc Runa | 0:3 | ||||
| 7. Round | 14/11/2020 | Guayaquil City | - | Mushuc Runa | 3:2 | ||||
| 8. Round | 19/11/2020 | Mushuc Runa | - | Olmedo | 1:1 | ||||
| 9. Round | 23/11/2020 | Universidad Catolica | - | Mushuc Runa | 1:1 | ||||
| 10. Round | 28/11/2020 | Mushuc Runa | - | Emelec | 2:3 | ||||
| 12. Round | 08/12/2020 | Mushuc Runa | - | Orense SC | 0:0 | ||||
| 14. Round | 17/12/2020 | Barcelona | - | Mushuc Runa | 3:0 | ||||
| 15. Round | 19/12/2020 | Mushuc Runa | - | Delfín SC | 2:0 |
Ecuador