| 1. Round | 24/07/2021 | Deportivo Guadalajara [U18] | - | Atlético San Luis [U18] | 6:0 | ||||
| 2. Round | 30/07/2021 | Puebla FC [U18] | - | Deportivo Guadalajara [U18] | 1:3 | ||||
| 3. Round | 07/08/2021 | Deportivo Guadalajara [U18] | - | FC Juárez [U18] | 1:2 | ||||
| 4. Round | 15/08/2021 | Santos Laguna [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U18] | - | Club León [U18] | 1:1 | ||||
| 6. Round | 21/08/2021 | CF Monterrey [U18] | - | Deportivo Guadalajara [U18] | 2:2 | ||||
| 7. Round | 28/08/2021 | Deportivo Guadalajara [U18] | - | Club Necaxa [U18] | 1:2 |  |
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| 9. Round | 18/09/2021 | Deportivo Guadalajara [U18] | - | CF Pachuca [U18] | 0:4 | ||||
| 14. Round | 20/10/2021 | Club Tijuana [U18] | - | Deportivo Guadalajara [U18] | 1:3 | ||||
| 16. Round | 30/10/2021 | UANL Tigres [U18] | - | Deportivo Guadalajara [U18] | 1:3 |  |
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| 17. Round | 05/11/2021 | Mazatlán FC [U18] | - | Deportivo Guadalajara [U18] | 2:1 |
Mexico