| 1. Round | 18/09/2021 | Leones Negros II | - | Gavilanes de Matamoros | 2:2 |  |
 |
||
| 2. Round | 25/09/2021 | Gavilanes de Matamoros | - | Coras de Nayarit | 0:0 | ||||
| 3. Round | 02/10/2021 | Mineros de Fresnillo FC | - | Gavilanes de Matamoros | 0:0 | ||||
| 4. Round | 09/10/2021 | Gavilanes de Matamoros | - | Tuzos de la UAZ | 2:1 | |
|||
| 5. Round | 14/10/2021 | Alacranes de Durango | - | Gavilanes de Matamoros | 1:0 | ||||
| 6. Round | 16/10/2021 | Gavilanes de Matamoros | - | Cimarrones de Sonora II | 2:1 | |
|||
| 7. Round | 23/10/2021 | Saltillo FC | - | Gavilanes de Matamoros | 3:1 | |
Mexico