| 1. Round | 25/06/2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 1:0 | ||||
| 2. Round | 03/07/2022 | Deportivo Guadalajara [U16] | - | Atlas Guadalajara [U16] | 2:1 | ||||
| 3. Round | 09/07/2022 | UANL Tigres [U16] | - | Deportivo Guadalajara [U16] | 1:3 |  |
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| 4. Round | 16/07/2022 | Deportivo Guadalajara [U16] | - | Club León [U16] | 4:2 | |
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| 6. Round | 30/07/2022 | Club Tijuana [U16] | - | Deportivo Guadalajara [U16] | 2:2 |  |
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| 7. Round | 06/08/2022 | Deportivo Guadalajara [U16] | - | CF Monterrey [U16] | 3:2 | ||||
| 8. Round | 13/08/2022 | Atlético San Luis [U16] | - | Deportivo Guadalajara [U16] | 0:0 | ||||
| 9. Round | 20/08/2022 | Deportivo Guadalajara [U16] | - | Mazatlán FC [U16] | 3:1 | ||||
| 10. Round | 27/08/2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 1:0 | ||||
| 11. Round | 03/09/2022 | Mazatlán FC [U16] | - | Deportivo Guadalajara [U16] | 1:2 | ||||
| 12. Round | 11/09/2022 | Deportivo Guadalajara [U16] | - | Atlético San Luis [U16] | 2:0 | ||||
| 17. Round | 15/10/2022 | Deportivo Guadalajara [U16] | - | UANL Tigres [U16] | 3:1 | |
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| 18. Round | 22/10/2022 | Atlas Guadalajara [U16] | - | Deportivo Guadalajara [U16] | 1:2 | |
Mexico