| 1. Round | 04/06/2022 | Banfield | - | Newell's Old Boys | 1:2 | ||||
| 2. Round | 10/06/2022 | Newell's Old Boys | - | San Lorenzo | 0:0 | ||||
| 3. Round | 14/06/2022 | Talleres de Córdoba | - | Newell's Old Boys | 0:1 | ||||
| 4. Round | 21/06/2022 | Newell's Old Boys | - | Argentinos Juniors | 1:0 |  |
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| 5. Round | 25/06/2022 | Estudiantes | - | Newell's Old Boys | 0:2 | |
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| 6. Round | 04/07/2022 | Newell's Old Boys | - | Patronato de Paraná | 2:2 | ||||
| 7. Round | 10/07/2022 | Platense | - | Newell's Old Boys | 1:1 | ||||
| 8. Round | 16/07/2022 | Newell's Old Boys | - | Racing Club | 0:0 | ||||
| 9. Round | 21/07/2022 | Rosario Central | - | Newell's Old Boys | 1:0 | ||||
| 10. Round | 25/07/2022 | Newell's Old Boys | - | Defensa y Justicia | 1:2 | ||||
| 11. Round | 31/07/2022 | Atlético Tucumán | - | Newell's Old Boys | 2:0 | ||||
| 12. Round | 08/08/2022 | Newell's Old Boys | - | Colón de Santa Fe | 0:0 | |
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| 13. Round | 14/08/2022 | River Plate | - | Newell's Old Boys | 4:1 | ||||
| 21. Round | 25/09/2022 | Independiente | - | Newell's Old Boys | 1:0 | ||||
| 27. Round | 24/10/2022 | Barracas Central | - | Newell's Old Boys | 1:1 | |
Argentina