| 26. Round | 06/02/2022 | FC Cartagena | - | UD Las Palmas | 0:2 | ||||
| 27. Round | 12/02/2022 | UD Ibiza | - | FC Cartagena | 2:1 |  |
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| 28. Round | 18/02/2022 | FC Cartagena | - | Real Valladolid | 2:3 | ||||
| 29. Round | 28/02/2022 | Málaga CF | - | FC Cartagena | 1:1 | ||||
| 35. Round | 08/04/2022 | CD Lugo | - | FC Cartagena | 1:0 | ||||
| 36. Round | 16/04/2022 | FC Cartagena | - | AD Alcorcón | 3:1 | ||||
| 42. Round | 29/05/2022 | CD Tenerife | - | FC Cartagena | 1:2 |  |
Argentina
Italy