| 1. Round | 31/07/2021 | Pumas Tabasco | - | Alebrijes de Oaxaca | 0:0 | ||||
| 2. Round | 04/08/2021 | Alebrijes de Oaxaca | - | Cimarrones de Sonora | 0:1 |  |
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| 3. Round | 11/08/2021 | Coyotes de Tlaxcala | - | Alebrijes de Oaxaca | 1:1 |  |
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| 4. Round | 18/08/2021 | Alebrijes de Oaxaca | - | Tepatitlán | 2:3 | |
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| 6. Round | 01/09/2021 | Alebrijes de Oaxaca | - | CF Monterrey II | 0:0 | ||||
| 8. Round | 14/09/2021 | Alebrijes de Oaxaca | - | Mineros de Zacatecas | 2:1 | ||||
| 9. Round | 24/09/2021 | Atlético Morelia | - | Alebrijes de Oaxaca | 1:0 | ||||
| 10. Round | 29/09/2021 | Alebrijes de Oaxaca | - | Tapatío | 0:1 | ||||
| 11. Round | 06/10/2021 | Venados FC | - | Alebrijes de Oaxaca | 1:1 | ||||
| 12. Round | 13/10/2021 | Alebrijes de Oaxaca | - | TM Fútbol Club | 2:2 | |
Mexico