| Group 7 | 03/03/2020 | Defensa y Justicia | - | Santos FC | 1:2 |  |
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| Group 7 | 10/03/2020 | Santos FC | - | Delfín SC | 1:0 | ||||
| Group 7 | 25/09/2020 | Delfín SC | - | Santos FC | 1:2 | ||||
| Group 7 | 01/10/2020 | Club Olimpia | - | Santos FC | 2:3 | |
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| Group 7 | 20/10/2020 | Santos FC | - | Defensa y Justicia | 2:1 | ||||
| Round of 16 | 24/11/2020 | LDU Quito | - | Santos FC | 1:2 | ||||
| Round of 16 | 01/12/2020 | Santos FC | - | LDU Quito | 0:1 | ||||
| Quarter-finals | 09/12/2020 | Grêmio Porto Alegre | - | Santos FC | 1:1 | |
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| Quarter-finals | 16/12/2020 | Santos FC | - | Grêmio Porto Alegre | 4:1 | |
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| Semi-finals | 06/01/2021 | Boca Juniors | - | Santos FC | 0:0 | ||||
| Semi-finals | 13/01/2021 | Santos FC | - | Boca Juniors | 3:0 | ||||
| Final | 30/01/2021 | Palmeiras | - | Santos FC | 1:0 |
Brazil