| Round of 16 | 18/02/2022 | Motagua | - | Seattle Sounders | 0:0 |  |
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| Round of 16 | 25/02/2022 | Seattle Sounders | - | Motagua | 5:0 |  |
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| Quarter-finals | 09/03/2022 | Seattle Sounders | - | Club León | 3:0 | ||||
| Quarter-finals | 18/03/2022 | Club León | - | Seattle Sounders | 1:1 | ||||
| Semi-finals | 07/04/2022 | Seattle Sounders | - | New York City FC | 3:1 | ||||
| Semi-finals | 14/04/2022 | New York City FC | - | Seattle Sounders | 1:1 | ||||
| Final | 28/04/2022 | Pumas UNAM | - | Seattle Sounders | 2:2 | ||||
| Final | 05/05/2022 | Seattle Sounders | - | Pumas UNAM | 3:0 |
USA