| 1. Round | 07/08/2021 | Rio Ave FC [Youth] | - | FC Vizela [Youth] | 3:0 |  |
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| 4. Round | 28/08/2021 | Sporting Braga [Youth] | - | Rio Ave FC [Youth] | 3:0 | ||||
| 5. Round | 11/09/2021 | Rio Ave FC [Youth] | - | CD Feirense [Youth] | 4:0 | ||||
| 6. Round | 18/09/2021 | FC Famalicão [Youth] | - | Rio Ave FC [Youth] | 4:0 | ||||
| 7. Round | 25/09/2021 | Leixões SC [Youth] | - | Rio Ave FC [Youth] | 0:2 | ||||
| 8. Round | 02/10/2021 | Rio Ave FC [Youth] | - | CD Tondela [Youth] | 1:2 | ||||
| 9. Round | 16/10/2021 | UD Oliveirense [Youth] | - | Rio Ave FC [Youth] | 1:4 | ||||
| 10. Round | 23/10/2021 | Rio Ave FC [Youth] | - | Gil Vicente [Youth] | 1:3 | ||||
| 3. Round | 27/10/2021 | Rio Ave FC [Youth] | - | FC Porto [Youth] | 1:0 | ||||
| 11. Round | 30/10/2021 | Vitória Guimarães [Youth] | - | Rio Ave FC [Youth] | 1:0 | ||||
| 12. Round | 06/11/2021 | FC Vizela [Youth] | - | Rio Ave FC [Youth] | 3:3 | ||||
| 15. Round | 30/11/2021 | Rio Ave FC [Youth] | - | Sporting Braga [Youth] | 1:0 | ||||
| 16. Round | 04/12/2021 | CD Feirense [Youth] | - | Rio Ave FC [Youth] | 0:2 | ||||
| 17. Round | 11/12/2021 | Rio Ave FC [Youth] | - | FC Famalicão [Youth] | 2:1 | ||||
| 19. Round | 08/01/2022 | CD Tondela [Youth] | - | Rio Ave FC [Youth] | 1:3 |
Guinea-Bissau