| 1. Round | 08/01/2022 | Puebla FC | - | CF América | 1:1 | ||||
| 2. Round | 16/01/2022 | UANL Tigres | - | Puebla FC | 0:2 | ||||
| 4. Round | 06/02/2022 | Gallos Blancos | - | Puebla FC | 0:2 | ||||
| 5. Round | 12/02/2022 | Puebla FC | - | Atlas Guadalajara | 1:1 | ||||
| 6. Round | 19/02/2022 | Puebla FC | - | CF Monterrey | 1:0 | ||||
| 7. Round | 27/02/2022 | Deportivo Guadalajara | - | Puebla FC | 2:3 |
Uruguay