| 1. Round | 23/07/2021 | FC Juárez [U20] | - | Deportivo Toluca [U20] | 0:1 | ||||
| 2. Round | 01/08/2021 | Deportivo Toluca [U20] | - | UANL Tigres [U20] | 2:0 | ||||
| 3. Round | 06/08/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 5. Round | 17/08/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 6. Round | 21/08/2021 | Atlas Guadalajara [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 7. Round | 29/08/2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 |  |
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| 8. Round | 13/09/2021 | CF Pachuca [U20] | - | Deportivo Toluca [U20] | 2:0 | ||||
| 9. Round | 18/09/2021 | Deportivo Toluca [U20] | - | CF América [U20] | 3:1 | ||||
| 11. Round | 22/09/2021 | CF Monterrey [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 10. Round | 26/09/2021 | Deportivo Toluca [U20] | - | Atlético San Luis [U20] | 2:0 |  |
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| 12. Round | 03/10/2021 | Deportivo Toluca [U20] | - | Gallos Blancos [U20] | 2:0 | |
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| 13. Round | 17/10/2021 | Deportivo Guadalajara [U20] | - | Deportivo Toluca [U20] | 4:1 | ||||
| 14. Round | 20/10/2021 | Deportivo Toluca [U20] | - | Club Necaxa [U20] | 0:1 | ||||
| 16. Round | 31/10/2021 | Deportivo Toluca [U20] | - | Club León [U20] | 1:0 |
Mexico